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Dear IDMU, What is the
difference between CBD & CBN. I hear a lot about
these & know they relate to cannabis but what are
they. I"ve been told that one particular kind is
found more in plants than resin & that one is better
for medicinal use than the other. Is this the case?
a number of cannabinoids, of which the most abundant
are THC (D9-tetrahydrocannabinol), CBD (cannabidiol) and CBN
(cannabinol). The active ingredient, which gets you
high, is THC. In the plant, CBD is a precursor and CBN
a metabolite of THC. As cannabis gets older, THC gradually
breaks down to CBN.
THC is the substance
found to have most psychoactive effect, and also the
most effect on symptoms such as pain or bronchospasm.
CBN and CBD are not psychoactive themselves, however
CBD can take the edge off a THC high, tending to relax
the user rather than increasing anxiety and paranoia.
CBD has also been found to have anticonvulsant properties
(potential value in treating epilepsy, MS, muscle spasms
etc), and recently published research has indicated
CBD to be effective in reducing neurotoxic brain damage
following strokes or head trauma. The proposed mechanism
of action also suggests CBD may offer some protection
against ecstasy-derived neurotoxicity (long-term depletion
of serotonergic receptors), although this has not specifically
been investigated. CBD is normally present in significant
quantities in hashish (cannabis resin), although in
most herbal cannabis or "skunk" the levels
of CBD are usually low or absent.
cannabis offers some advantages over oral preparations
(rapid onset of action, ability to control dose), the
smoke contains carcinogens, tars and other lung irritants
which may cause respiratory diseases and lung cancer.
The lack of an effective filter in "roaches"
and the deep inhalation techniques used by cannabis
smokers increases this risk. However the study of smoke
composition quoted by the BMA and others referred to
poor quality herbal cannabis smoked "neat",
and the relevance of these results to tobacco/hash spliffs
or high-THC varieties is questionable. At least one
pharmaceutical company is developing alternative quick-acting
delivery systems for plant-derived cannabinoid combinations,
avoiding the need for smoking.